Diaphragm Ultrasound to Predict Weaning Outcomes in Mechanically Ventilated Patients

Completed

• Conditions: Accuracy of DE and DTF in Prediction of Extubation Success

• Registration Number: NCT03480828
• Lead Sponsor: Mongi Slim Hospital

Brief Summary

This trial enrolled all the adult patients who were mechanically ventilated for more than 48 hours and met all creteria for extubation. Patients who needed reintubation for upper aiway obstruction, neurological or hemodynamic alteration were excluded. The diaphragm ultrasound was performed during spontaneous breathing test or pressure support ventilation trial measuring the dipahragmatic excursion (DE) and the diaphragm thickening fraction (DTF) whithin 24 hours before extubation.

Detailed Description

This trial enrolled all the adult patients who were mechanically ventilated for more than 48 hours and met all creteria for extubation. Patients who needed reintubation for upper aiway obstruction, neurological or hemodynamic alteration were excluded. The diaphragm ultrasound was performed during spontaneous breathing test or pressure support ventilation trial measuring the dipahragmatic excursion (DE) and the diaphragm thickening fraction (DTF) whithin 24 hours before extubation. The investigators compared the median values of DE and DTF in the group of successfully extubated patients and the group of patients who needed reintubation.

Our study compared the utility of DTF and DE to predict extubation success.

Study Timeline

• Study Start: 2017-04-01
• Primary Completion: 2017-12-31
• Study Completion: 2017-12-31
• Status Verified: 2018-03
• Study First Submitted: 2018-03-22
• Study First Submitted QC: 2018-03-22
• Last Update Submitted: 2018-03-28
• Study First Posted: 2018-03-29
• Last Update Posted: 2018-03-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• patients who were mechanically ventilated for more than 48h and meeting all criteria for extubation
• patients without history of neuromuscular disease, or severe chronic respiratory failure

Exclusion Criteria

• patients who needed reintubation for upper airway obstruction or neurological or hemodynamic instability

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
extubation success	48 hours after extubation	comparaison between DE and DTF values in successfully extubated patients

Trial Locations

Locations (1)

Mongi Slim Hospital; 🇹🇳 La Marsa, Tunis, Tunisia