Prospective Registry of Outcomes and Management of Acute Ischaemic Syndromes
- Conditions
- Acute Coronary SyndromesCoronary Artery Disease
- Registration Number
- NCT00716352
- Lead Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
- Brief Summary
This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated, half received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months. Longer term follow up through the Office Of National Statistics will be performed.
- Detailed Description
This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated. A cluster randomised method was used and half of centres received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months and longer term follow up for mortality will be performed through the national databases.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1340
All patients admitted to the hospital (either through casualty or directly to the wards), with a good clinical history of an acute coronary syndrome with one or more of the following:
- Ischaemic changes on the admission ECG (including patients with bundle branch block)
- Elevated Troponin or cardiac enzymes on admission
- Normal ECGs but with evidence of pre-existing coronary artery disease i.e., evidence of a prior history of MI, coronary revascularisation, coronary angiography demonstrating the presence of significant coronary stenosis or a stress test demonstrating ischaemia (treadmill, echo or nuclear scan)
Written informed consent
- Patients with persistent ST elevation >1mm in two or more contiguous leads on the ECG.
- Patients treated with thrombolytic therapy, or for whom thrombolytic therapy was considered on admission.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Adherence to the educational programme measured by the frequency of use of the evidence based treatments: Aspirin, Heparin, Clopidogrel, Beta blockers, Statins.
- Secondary Outcome Measures
Name Time Method Comparison of investigations and tests Use of other treatments Counselling for lifestyle changes Referral to smoking cessation clinics Cardiac rehabilitation Compliance to treatment at 6 months Comparison of clinical events at 6 months
Trial Locations
- Locations (37)
Darent Valley Hospital
🇬🇧Dartford, United Kingdom
Eastbourne District General Hospital
🇬🇧Eastbourne, United Kingdom
Western Infirmary
🇬🇧Glasgow, United Kingdom
Withybush General Hospital
🇬🇧Haverfordwest, United Kingdom
Whiston Hospital
🇬🇧Prescot, United Kingdom
Hope Hospital
🇬🇧Salford, United Kingdom
University Hospital Of North Tees
🇬🇧Stockton-on-Tees, United Kingdom
Taunton and Somerset Hospital
🇬🇧Taunton, United Kingdom
Wordsley Hospital
🇬🇧Stourbridge, United Kingdom
Pinderfields General Hospital
🇬🇧Wakefield, United Kingdom
Royal Albert Edward Infirmary
🇬🇧Wigan, United Kingdom
Monklands Hospital
🇬🇧Airdrie, United Kingdom
Barnet General Hospital
🇬🇧Barnet, United Kingdom
Barnsley District General Hospital
🇬🇧BArnsley, United Kingdom
University Hospital Aintree
🇬🇧Aintree, United Kingdom
Antrim Hospital
🇬🇧Antrim, United Kingdom
North Hampshire Hospital
🇬🇧Basingstoke, United Kingdom
Mater Infirmorum Hospital
🇬🇧Belfast, United Kingdom
Basildon Hospital
🇬🇧Basildon, United Kingdom
Bridlington And District Hospital
🇬🇧Bridlington, United Kingdom
Birmingham Heartlands Hospital
🇬🇧Birmingham, United Kingdom
Royal Victoria Hospital
🇬🇧Belfast, United Kingdom
The Royal Sussex County Hospital
🇬🇧Brighton, United Kingdom
Leighton Hospital
🇬🇧Crewe, United Kingdom
Altnagelvin Area Hospital
🇬🇧Londonderry, United Kingdom
Royal Alexandra Hospital
🇬🇧Paisley, United Kingdom
Cumberland Infirmary
🇬🇧Carlisle, United Kingdom
Macclesfield District General Hospital
🇬🇧Macclesfield, United Kingdom
Luton and Dunstable Hospital
🇬🇧Luton, United Kingdom
Northampton General Hospital
🇬🇧Northampton, United Kingdom
Pontefract General Infirmary
🇬🇧Pontefract, United Kingdom
Oldchurch Hospital
🇬🇧Romford, United Kingdom
Rotherham District General Hospital
🇬🇧Rotherham, United Kingdom
Torbay Hospital
🇬🇧Torquay, United Kingdom
West Cumberland Hospital
🇬🇧Whitehaven, United Kingdom
University Hospital Of North Staffordshire
🇬🇧Stoke-on-Trent, United Kingdom
Wrexham Maelor Hospital
🇬🇧Wrexham, United Kingdom