NCT04081740已完成不适用
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Measurement of crossover stress (mucus rheology)
研究概览
简要总结
The primary objective of this study is to investigate the biological determinants of sputum rheology variations.
详细描述
Secondarily, this study aims to compare rheology parameters between different chronic airway disease sub-populations.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Affiliate with or beneficiary of the French national single-payer health insurance system
- •Patient capable of spontaneous mucus expectoration
- •Consulting or hospitalized at the study centre
- •Inclusion Criteria for the Asthma Group
- •Never- or former-smoker (<10 pack-years)
- •Medical history compatible with asthma
- •Reversible post-brochodilator (or post-corticosteroid test) ventilatory obstruction (ratio of forced expiratory volume in 1 second : forced vital capacity < 70%) or significant variation in respiratory function -- OR -- Bronchial hyperresponsiveness demonstrated during a broncho-provocation test
- •Inclusion Criteria for the COPD Group
- •Current- or former-smokers (>10 pack years)
- •Chronic obstructive pulmonary disease according to GOLD criteria
- •Inclusion Criteria for the Bronchiectasis Group
- •Presence of bronchiectasis on computed tomography scan
- •Cystic fibrosis has been ruled out
排除标准
- •Patient expresses opposition to the protocol
- •Breast feeding or pregnant
- •Metastatic neoplastic disease
- •Other active pulmonary disease (tuberculosis, interstitial lung disease)
- •Recent psychiatric disorder (in the past year and documented via a specialist consult)
- •Consumption of illicit drugs or alcoholism
- •Patients in an exclusion period determined by another study
- •Patients under any type of legal guardianship
- •Prisoners
- •Impossible to correctly inform the patient
- •Does not fluently read French
- •Emergency situations
结局指标
主要结局
Measurement of crossover stress (mucus rheology)
时间窗: Day 0
The crossover stress point for each mucus sample will be measured in Pa.
次要结局
- Measurement of the storage modulus (mucus rheology)(Day 0)
- Measurement of the strain crossover (mucus rheology)(Day 0)
- Measurement of the loss modulus (mucus rheology)(Day 0)
- Measurement of the loss factor (mucus rheology)(Day 0)
研究者
研究点 (1)
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