Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage
- Registration Number
- NCT01863706
- Lead Sponsor
- Hormozgan University of Medical Sciences
- Brief Summary
Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available. The aim of this study is to compare the safety and efficacy of Oxytocin and misoprostol for prevention of PPH.
- Detailed Description
In a double blind randomized controlled trial 400 pregnant women who has vaginal delivery at Shariati hospital are assigned into two groups either to receive 20 unite oxytocin in 1000cc ringer and 2 placebo tablet or 400mcg oral misoprostol and 2cc normal saline in 1000cc ringer.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 400
Inclusion Criteria
- were women with singleton pregnancy
- with cephalic presentation
- who had NVD spontaneously or by induction
Exclusion Criteria
- placenta previa
- placental detachment
- coagulation problems
- previous CS
- macrosomia
- Polyhydramnios
- and uncontrolled asthma
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Misoprostol Misoprostol 400µg oral misoprostol Oxytocin Oxytocin 20 IU oxytocin
- Primary Outcome Measures
Name Time Method Amount of bleeding 1 hour within 1 hours after delivery
- Secondary Outcome Measures
Name Time Method Hematocrite decrease 24 hours Hemoglobin decrease 24 hours
Trial Locations
- Locations (1)
Hormozgan University of Medical Sciences
🇮🇷Bandar Abbas, Hormozgan, Iran, Islamic Republic of