Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section

Phase 2

Completed

• Conditions: Postpartum Hemorrhage
• Interventions: Drug: Oxytocin; Drug: Carbetocin

• Registration Number: NCT02079558
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Postpartum hemorrhage (PPH) is a common complication of childbirth and a leading cause of maternal morbidity and mortality. The prompt and effective treatment of subjects with PPH would reduce operation risks. Hence in this study, the efficacy of Oxytocin and Carbetocin was compared in prevention of postpartum hemorrhage after cesarean sections.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-09
• Primary Completion: 2013-09
• Study Completion: 2013-09
• Study First Submitted: 2014-01-13
• Status Verified: 2014-03
• Study First Submitted QC: 2014-03-04
• Last Update Submitted: 2014-03-04
• Study First Posted: 2014-03-06
• Last Update Posted: 2014-03-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 220

Inclusion Criteria

• At least one risk for postpartum hemorrhage and lack of hypersensitivity to oxytocin and carbetocin

Exclusion Criteria

• Patients' refusal to cooperate, major therapeutic side effects, history of cardiac and renal disease or preeclampsia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Oxytocin	Oxytocin	A single 100 microgram IV dose of carbetocin after operation
Carbetocin	Carbetocin	A standard 30 international units (IU) IV infusion of oxytocin during two hours

Primary Outcome Measures

Name	Time	Method
screening of Cessation of bleeding	screening until 24 hours after placenta disconnection
time duration to stop bleeding in the case of post-cesarean section	24 hours

Trial Locations

Locations (1)

Infertility and Reproductive Health Research Center; 🇮🇷 Tehran, Iran, Islamic Republic of