Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Enrollment
- 220
- Locations
- 1
- Primary Endpoint
- screening of Cessation of bleeding
Study Overview
Brief Summary
Postpartum hemorrhage (PPH) is a common complication of childbirth and a leading cause of maternal morbidity and mortality. The prompt and effective treatment of subjects with PPH would reduce operation risks. Hence in this study, the efficacy of Oxytocin and Carbetocin was compared in prevention of postpartum hemorrhage after cesarean sections.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Screening
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •At least one risk for postpartum hemorrhage and lack of hypersensitivity to oxytocin and carbetocin
Exclusion Criteria
- •Patients' refusal to cooperate, major therapeutic side effects, history of cardiac and renal disease or preeclampsia
Arms & Interventions
Oxytocin
A single 100 microgram IV dose of carbetocin after operation
Intervention: Oxytocin (Drug)
Carbetocin
A standard 30 international units (IU) IV infusion of oxytocin during two hours
Intervention: Carbetocin (Drug)
Outcomes
Primary Outcomes
screening of Cessation of bleeding
Time Frame: screening until 24 hours after placenta disconnection
time duration to stop bleeding in the case of post-cesarean section
Time Frame: 24 hours
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr Robabeh Taheripanah
Associated prof. Obstetrics & Gynecology
Shahid Beheshti University of Medical Sciences