Spontaneous breathing and work-of-breathing in mechanically ventilated childre

Withdrawn

Conditions: distribution of ventilation
Lung mechanics
work of breathing
10038716

Registration Number: NL-OMON36671

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 15

Inclusion Criteria

*mechanical ventilation for at least 24hours
*weight> 3kg
*able to initiate and maintain spontaneous breathing
*stable ventilator settings, defined by the absence of need for increase of inspiratory pressures or positive end-expiratory pressure, and a FiO2 < 0.4 for at least 6 hours prior to enrollment
*stable haemodynamics, defined by the absence of need for increase in vaso-active drugs and/or fluid challenges at least 6 hours prior to enrolment
*leakage around the endotracheal tube less then 5%, defined by the ratio of the expiratory tidal volume both to the inspiratory tidal volume measured by the ventilator

Exclusion Criteria

*mechanical ventilation less than 24hours
*unstable ventilator settings, defined by the need for increase of inspiratory pressures or positive end-expiratory pressure, and a FiO2 > 0.6 within 6 hours prior to enrolment
*unstable haemodynamics, defined by the need for increase in vaso-ative drugs and/or fluid challenges within 6 hours prior to enrolment
*leakage around the endotracheal tube > 5%
*admitted to the neonatal intensive care unit
*premature birth with gestational age corrected for age less than 40 weeks
*congenital or acquired neuromuscular disorders
*congenital or acquired central nervous system disorders with depressed respiratory drive
*congenital or acquired damage to the phrenic nerve
*congenital or acquired paralysis of the diaphragm
*use of neuromuscular blockade prior to enrolment
*uncorrected congenital heart disorder
*chronic lung disease

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* Global lung aeration before and during spontaneous breathing during<br /><br>mechanical ventilation</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Work of breathing at various pressure support levels during spontaneous<br /><br>breathing:<br /><br>-Area of the oesophageal pressure - volume curve<br /><br>-Oesophageal pressure * time product<br /><br>-Oesophageal pressure * rate product<br /><br><br /><br>Patient comfort at various pressure support levels during spontaneous breathing</p><br>