Neotech RAM Cannula Versus Conventional Binasal Prong Continuous Positive Airway Pressure (CPAP) to Treat Respiratory Distress in Low Birth Weight Neonates
Not Applicable
Terminated
- Conditions
- Respiratory Distress Syndrome, NewbornLow Birth Weight InfantsContinuous Positive Airway Pressure
- Registration Number
- NCT02168257
- Lead Sponsor
- Children's Hospitals and Clinics of Minnesota
- Brief Summary
The purpose of this study is to determine if the RAM cannula is as effective as conventional binasal prongs to deliver CPAP to low birth weight infants with respiratory distress.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
- Low Birth Weight Infant
- Currently on continuous positive aireway pressure of 5-7 cm water pressure
- Receiving continuous positive airway pressure support for > 24 hrs prior to enrollment
- Fraction of inspired oxygen requirement of 23-50%
Exclusion Criteria
- Fraction of inspired oxygen > 50%
- Congenital defects of head, pulmonary or cardiovascular systems
- Chromosomal abnormalities/genetic syndromes
- Invasive Surgical Procedure within 24 hrs prior to enrollment
- Enrollment in separate clinical trial that has ongoing data collection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Oxygenation 3 hrs Pulse oximetry
Ventilation 3 hrs transcutaneous carbon dioxide monitor
- Secondary Outcome Measures
Name Time Method Esophageal pressure measurements 3 hrs Esophageal Pressure Catheter
Apnea 3 hrs 3-channel pneumogram
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms by which RAM cannula improves oxygenation in low birth weight infants with respiratory distress syndrome?
How does the efficacy of RAM cannula compare to conventional binasal prongs in maintaining alveolar stability for preterm neonates on CPAP?
Are there specific biomarkers that indicate optimal patient selection for non-invasive respiratory support using RAM cannula in neonatal intensive care?
What adverse events are associated with RAM cannula versus binasal prong CPAP in low birth weight infants and how are they managed?
What combination therapies or alternative devices are being explored alongside CPAP for treating respiratory distress in RAS mutant low birth weight neonates?
Trial Locations
- Locations (1)
Children's Hospitals and Clinics of Minnesota
🇺🇸Saint Paul, Minnesota, United States
Children's Hospitals and Clinics of Minnesota🇺🇸Saint Paul, Minnesota, United States