Cognitive-enhancing DA Medications for Cocaine Dependence
Overview
- Phase
- Phase 2
- Intervention
- levodopa/carbidopa
- Conditions
- Cocaine Dependence
- Sponsor
- The University of Texas Health Science Center, Houston
- Enrollment
- 119
- Locations
- 1
- Primary Endpoint
- Cocaine Use Based on Urine Drug Screening
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to evaluate treatments designed to improve cocaine treatment success by combining medications that target cocaine-related cognitive impairments.
Investigators
Joy Schmitz
Professor - Psychiatry
The University of Texas Health Science Center, Houston
Eligibility Criteria
Inclusion Criteria
- •meet criteria for cocaine dependence
- •seeking treatment for cocaine dependence
- •be in acceptable health based on medical history and physical exam
Exclusion Criteria
- •dependent on drugs other than cocaine, nicotine, marijuana
- •have a medical condition contraindicating treatment with study medications
- •having conditions of probation or parole requiring reports of drug use to officers of the court
Arms & Interventions
ldopa + ropinirole low dose
levodopa/carbidopa 800/200 mg/d plus ropinirole 2 mg/d
Intervention: levodopa/carbidopa
ldopa + ropinirole low dose
levodopa/carbidopa 800/200 mg/d plus ropinirole 2 mg/d
Intervention: Ropinirole 2 mg/d
ldopa + ropinirole high dose
levodopa/carbidopa 800/200 mg/d plus ropinirole 4 mg/d
Intervention: levodopa/carbidopa
ldopa + ropinirole high dose
levodopa/carbidopa 800/200 mg/d plus ropinirole 4 mg/d
Intervention: Ropinirole 4 mg/d
ldopa
levodopa/carbidopa 800/200 mg/d
Intervention: levodopa/carbidopa
placebo
Placebo
Intervention: Placebo
Outcomes
Primary Outcomes
Cocaine Use Based on Urine Drug Screening
Time Frame: 10 weeks
The mean of the predicted probabilities (derived from generalized linear mixed models) of negative drug screens over all 10 weeks is reported, as per the analysis proposed in the protocol.
Secondary Outcomes
- Number of Participants Who Completed the 10 Week Trial(10 weeks)