Maximizing the Efficacy of Cognitive Behavioral Therapy With Medication and Contingency Management
Overview
- Phase
- Phase 1
- Intervention
- Placebo
- Conditions
- Cocaine Abuse
- Sponsor
- Yale University
- Enrollment
- 181
- Locations
- 1
- Primary Endpoint
- Change in Cocaine Use by Self Report
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).
Detailed Description
This study will compare four types of treatment involving skills training and incentives for attending sessions or taking study medication. Disulfiram is a widely prescribed deterrent to alcohol use. In addition to weekly cognitive behavioral therapy (CBT), participants will be assigned to one of the following treatments: 1. placebo 2. disulfiram 3. placebo plus incentives for cocaine abstinence and medication compliance (prize CM) 4. disulfiram plus incentives for cocaine abstinence and medication compliance
Investigators
Eligibility Criteria
Inclusion Criteria
- •18-50 year old
- •cocaine dependent
- •willing to sign consent
- •willing to accept randomization to intervention
Exclusion Criteria
- •significant medical conditions
- •psychiatric disorder with current use of prescribed psychotropic medication
- •lifetime schizophrenia or bipolar disorder
- •suicidality or homicidality
- •unlikely to be able to complete 1 year follow up
- •unable to speak or read English at a third grade level
Arms & Interventions
Placebo
Placebo (plus Cognitive Behavioral Therapy- CBT)
Intervention: Placebo
Disulfiram
Disulfiram (plus CBT)
Intervention: disulfiram
Placebo plus Contingency Management
Placebo plus Contingency Management for cocaine abstinence and medication compliance (in addition to CBT).
Intervention: Placebo plus Contingency Management
Disulfiram plus Contingency Management
Disulfiram plus Contingency Management for cocaine abstinence and medication compliance (in addition to CBT).
Intervention: Disulfiram plus Contingency Management
Outcomes
Primary Outcomes
Change in Cocaine Use by Self Report
Time Frame: 12 weeks
Self-reports of substance use will be documented at each contact via the Substance Use Calendar. Similar to the Form-90 and the Time Line Follow-Back, which have been shown to be reliable and valid instruments for monitoring substance use and other outcomes in longitudinal studies202-204, the Substance Use Calendar allows a flexible, continuous evaluation of substance use on a daily basis.
Change in Cocaine Use by Urine Toxicology Results
Time Frame: 12 weeks
We will use the Roche onsite TESTCUP system for detection of cocaine, methamphetamine, THC, benzodiazepenes, and opioids.