Biomarker for Rapid Diagnosis of Hemispheric Stroke

Completed

• Conditions: Acute Stroke

• Registration Number: NCT00916864
• Lead Sponsor: Johann Wolfgang Goethe University Hospital

Brief Summary

The aim of the study is to estimate the diagnostic accuracy of a combined biomarker test (including NMDA-Receptor fragments \[NR2-peptide\] and Glial fibrillary acidic protein) used to differentiate between cerebral ischemia and intracerebral hemorrhage in patients with acute hemispheric stroke.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-06-09
• Study First Submitted QC: 2009-06-09
• Study First Posted: 2009-06-10
• Status Verified: 2011-06
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Last Update Submitted: 2011-06-22
• Last Update Posted: 2011-06-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• hemiparesis
• at least one sign of cortical involvement (e.g., aphasia, neglect, gaze deviation, reduced level of consciousness)
• hospital admission within 4.5 hours after symptom onset

Exclusion Criteria

• stroke/TIA within the last 3 months
• traumatic brain injury within the last 3 months
• history of brain tumor

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnostic accuracy (sensitivity and specificity for diagnosing cerebral ischemia and intracerebral hemorrhage)	9 months

Trial Locations

Locations (1)

Department of Neurology, Goethe-University; 🇩🇪 Frankfurt am Main, Germany