Chemoreflex inactivation, arterial stiffness and exercising muscle blood flow in human hypertensio

Not Applicable

• Conditions: Hypertension; Respiratory - Normal development and function of the respiratory system; Cardiovascular - Hypertension

• Registration Number: ACTRN12622000428763
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-03-16
• Last Update Posted: 21 March 2022

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Participants with essential hypertension (At least Stage 2 hypertension; untreated office SBP > 140 mmHg or DBP > 90 mmHg)
- Normotensive controls (office SBP < 120 mmHg and DBP < 80 mmHg)
- Men and women
- Aged over 18 years
- Body mass index < 35 kg/m2

Exclusion Criteria

- Significant arrhythmias (e.g., atrial fibrillation, previous VT / significant ventricular ectopy)
- Significant valvular heart disease
- Previous coronary artery bypass surgery
- Primary angioplasty for acute ST elevation
- Myocardial infarction
- Severe left ventricular dysfunction
- Recent (< 3 months) ischemic stroke
- Current smoker
- Body mass index < 18 kg·m2
- Current pregnancy
- Users of recreational drugs
- Abusers of alcohol
- Inability to fully or appropriately provide consent (e.g., language issue, reading capability)
- Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified