Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers
Completed
- Conditions
- Multiple Sclerosis
- Registration Number
- NCT05561621
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Brief Summary
The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue. Up to now, to the best of the investigator's knowledge, there is no study reporting the use of vocal biomarkers to predict these three non-motor symptoms in people with MS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
- Relapsing MS
- Age over 18
- EDSS < 4.0
- Capability of written informed consent
Exclusion Criteria
- Not fluent in german language
- Relapse or Steroids per os/intra venous < 4 weeks prior to examination
- KM enhancing lesion in MRI < 4 weeks prior to examination
- Other previous disease affecting the speech
- Pregnant patients
- Mental disability and not able to understand the protocol and study tasks in german languagePatients with greater physical and cognitive disability or history of major depressive disorder and suicide attempt/suicidal thoughts
- Patients with sleep disorders and comorbidities associated with extreme fatigue (e.g., fibromyalgia)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of a voice signature that separates between pwMS with and without fatigue One year
- Secondary Outcome Measures
Name Time Method Identification of a voice signature that separates between pwMS with and without depression One year Identification of a voice signature that separates between pwMS with and without cognitive impairment One year
Trial Locations
- Locations (1)
Inselspital University Hospital Bern
🇨🇭Bern, Switzerland
Inselspital University Hospital Bern🇨🇭Bern, Switzerland