Auditory Functions in Patients With Multiple Sclerosis
- Conditions
- Multiple SclerosisHearing Disorders
- Registration Number
- NCT06164483
- Lead Sponsor
- University of Catania
- Brief Summary
The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers.
The results of DPOAE and CSF will be correlated to identify statistically significant correlation.
- Detailed Description
Case-Control study
Tools for patients' selection and inclusion in the study
STEP one
* Full medical records detailed for neurological diseases
* Brain and spinal cord MRI performed 12 months (n1) before and most recent one (n2)
* Lumbar puncture
* Blood test
* Questionnaire for screening hearing disorders
* App for screening hearing loss
STEP two
* Pure Tone Auditory test + Tympanometry and Stapedial Reflex
* Speech Perception test
* In case of tinnitus: tinnitus questionnaire and acuphenometry
* DPOAEs
* ABR
STEP three in case of Hearing impairment
- MRI Tractography
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Auditory functions and correlation with CSF findings 12 months The worsening of the hearing thresholds and DPOAE results will be correlated with the presence of inflammatory elements in the CSF
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Arianna Di Stadio
🇮🇹Catania, Sicily, Italy
Arianna Di Stadio🇮🇹Catania, Sicily, Italy