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Auditory Functions in Patients With Multiple Sclerosis

Recruiting
Conditions
Multiple Sclerosis
Hearing Disorders
Registration Number
NCT06164483
Lead Sponsor
University of Catania
Brief Summary

The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers.

The results of DPOAE and CSF will be correlated to identify statistically significant correlation.

Detailed Description

Case-Control study

Tools for patients' selection and inclusion in the study

STEP one

* Full medical records detailed for neurological diseases

* Brain and spinal cord MRI performed 12 months (n1) before and most recent one (n2)

* Lumbar puncture

* Blood test

* Questionnaire for screening hearing disorders

* App for screening hearing loss

STEP two

* Pure Tone Auditory test + Tympanometry and Stapedial Reflex

* Speech Perception test

* In case of tinnitus: tinnitus questionnaire and acuphenometry

* DPOAEs

* ABR

STEP three in case of Hearing impairment

- MRI Tractography

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
30
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Auditory functions and correlation with CSF findings12 months

The worsening of the hearing thresholds and DPOAE results will be correlated with the presence of inflammatory elements in the CSF

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Arianna Di Stadio

🇮🇹

Catania, Sicily, Italy

Arianna Di Stadio
🇮🇹Catania, Sicily, Italy

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