Effect of Motor Entrainment to Auditory Cues and Music During Walking on Quality of Movement and Percieved Fatigue in Persons with Multiple Sclerosis with Cerebellar Lesions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Hasselt University
- Enrollment
- 8
- Locations
- 2
- Primary Endpoint
- Resultant Vector Length
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This study is a case-control observational study, involving persons with multiple sclerosis and healthy controls. The study contains 1 descriptive and 4 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, at different tempi and alignment strategies. In the latter three sessions, apart from outcome measures of synchronization the following will be collected as well: spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.
Investigators
Peter Feys
Principal Investigator
Hasselt University
Eligibility Criteria
Inclusion Criteria
- •diagnosis of Multiple sclerosis \>1 year,
- •type of lesions: cerebellar lesions,
- •walking speed 0.8-1.2m/s, ability to walk for 6 minutes continuously (canes and rollators are permitted).
Exclusion Criteria
- •relapse 3 months prior to enrollment,
- •cognitive impairment impeding understanding of instructions,
- •beat amusia,
- •deafness,
- •pregnancy
Outcomes
Primary Outcomes
Resultant Vector Length
Time Frame: week 5
synchronisation consistency
EEG
Time Frame: week 2
64 channel EEG measurement (only conducted in 4 PwMS and HC) -\> neural correlates of entrainment
Muscle weakness
Time Frame: week 1
Motricity Index of dorsi flexors, knee extensors and hip flexors -
Perceptual tempo and rhythm judgements
Time Frame: week 2
subjective indications in regards to what the participants hear in terms
6 minute walking test
Time Frame: week 1
gait pattern and endurance
Brief repeatable battery of Rao
Time Frame: week 1
cognitive test
MS walking scale -12
Time Frame: week 1
impact of MS on walking ability
Spasticity
Time Frame: week 1
Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts
Ataxia
Time Frame: week 1
Scale for the assessment and rating of ataxia
Time up and Go test
Time Frame: week 1
balance
Symbol digit mobility test
Time Frame: week 1
cognitive test
Stroop test 0
Time Frame: week 1
cognitive test
Modified fatigue impact scale
Time Frame: week 1
effect of fatigue
Dual task questionnaire
Time Frame: week 1
troubles a person have when performing a dual task during daily activity
Relative phase angle
Time Frame: week 5
asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively)
Asynchrony
Time Frame: week2
timing difference between the tap and the beat
Dynamic gait index
Time Frame: week 1
dynamic balance
Activities-specific balance confidence scale
Time Frame: week 1
rating of balance confidence in performing activities of daily life
Hospital Anxiety and Depression Scale
Time Frame: week 1
determine the levels of anxiety and depression
Secondary Outcomes
- Cadence(week 5)
- Stride length(week 5)
- Perceived cognitive and physical fatigue(week 5)
- Perceived walking speed(week 5)
- speed(week 5)
- Double Support(week 5)
- Perceived motivation(week 5)