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临床试验/NCT06448858
NCT06448858尚未招募不适用

Effect of Body Composition on Some Blood Minerals Status in Obese and Overweight Adolescent; Cross Sectional Study

Assiut University1 个研究点 分布在 1 个国家目标入组 84 人开始时间: 2024年6月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
84
试验地点
1
主要终点
concentration of serum Manganese

研究概览

简要总结

Evaluation of the concentration of serum Mn, Se, iron, Cu & Zn levels in obese and overweight adolescents, Correlate the body composition parameters with these minerals' concentration, Study the association between the metabolic risk factors and the disturbance in minerals levels in these patients.

详细描述

Obesity in the population tends to be a notable public health threat on the global scale . individuals with higher body mass index (BMI) are considered to have a lower life expectancy . Among the obesity-related indicators, visceral adipose tissue (VAT) is acknowledged an emerging and sensitive predictor for the risk of metabolic syndrome and cardiovascular disease . Therefore, adverse VAT accumulation can influence metabolic health in the population, and its related risk factors should be further investigated.

Micronutrients in obese people are explored because of an excess energy consumption, and therefore, an inadequate intake of trace elements and minerals. This imbalance among energy consumption and the intake is known as hidden hunger. Obesity can lead to nutritional metabolic disorders, in which the general state of trace elements and minerals are altered.

Only a few studies on child and adolescents obesity concerned Trace Elements (TE). TE is involved in the pathogenesis of obesity and obesity related diseases. We tried to assess trace elements status [ Manganese (Mn), selenium (Se) copper (Cu),zinc (Zn)] in obese children and their relationships with VAT and metabolic risk factors of obesity.

Manganese (Mn) is an essential trace element . It plays an important role in fat metabolism.

Selenium (Se) is an essential micronutrient that acts as an antioxidant and possesses multiple metabolic properties.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
12 Years 至 18 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • Patients in adolescent age (12-18 years old)
  • Patients with BMI over 25.

排除标准

  • Patients younger than 12 years old or older than 18 years old.
  • Patients with history of chronic use of mineral and /or vitamin supplements .
  • Patients with syndromal obesity , endocrine disorder and history of any chronic diseases ,
  • Patients under special diets or chronic use of medication .

结局指标

主要结局

concentration of serum Manganese

时间窗: 1 year

Evaluate the concentration of serum Mn levels in obese and overweight adolescents.

Concentration of serum Iron

时间窗: 1 year

Evaluate the concentration of serum Iron levels in obese and overweight adolescents.

Concentration of serum Zinc

时间窗: 1 year

Evaluate the concentration of serum Zn levels in obese and overweight adolescents.

Concentration of serum selenium

时间窗: 1 year

Evaluate the concentration of serum Se levels in obese and overweight adolescents.

Concentration of serum copper

时间窗: 1 year

Evaluate the concentration of serum Cu levels in obese and overweight adolescents.

次要结局

  • Visceral fat and it's relation to mineral levels(1 year)
  • BMI and its relation to mineral levels(1 year)
  • Body fat percentage and it's relation to mineral level(1 year)
  • Basal metabolic rate and it's relation to mineral levels(1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dalia Hussien Abdelmoneim Hassan

Resident doctor

Assiut University

研究点 (1)

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