Lung Cancer Screening Eligibility Assessment

Not Applicable

Active, not recruiting

• Conditions: Lung Cancer
• Interventions: Behavioral: Framed Introductory Message A; Behavioral: Framed Introductory Message C; Behavioral: Framed Introductory Message B; Behavioral: Framed Tobacco Use Message A; Behavioral: Framed Tobacco Use Message B; Behavioral: Financial Incentive

• Registration Number: NCT06133816
• Lead Sponsor: Abramson Cancer Center at Penn Medicine

Brief Summary

The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help inform the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Detailed Description

Despite growing evidence that lung cancer screening (LCS) reduces lung cancer-specific mortality, LCS across the United States is remarkably low. This is due in part to challenges with identifying adults who meet eligibility criteria for lifetime smoking intensity (i.e., 20 pack-years or greater), which is often missing from the electronic medical record. We have developed a simplified eligibility tool that has shown accuracy in estimating pack-years. But given the potential for low response rates, there is a great need to identify effective strategies to increasing response rates equitably prior to using it in practice or in future studies. The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help to identify the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Study Timeline

• Study Start: 2023-07-31
• Study First Submitted: 2023-10-18
• Study First Submitted QC: 2023-11-10
• Study First Posted: 2023-11-18
• Primary Completion: 2024-01-31
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-02
• Last Update Posted: 2024-10-03
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 6000

Inclusion Criteria

1. meet age eligibility (50-80 years old) for LCS based on 2021 USPSTF guidelines; and
2. have completed at least one primary care visit at Penn Medicine in 2020-2025

Exclusion Criteria

1. have a documented history of lung cancer;
2. have a documented history of completing LCS at Penn Medicine;
3. are listed as not wanting to be contacted or solicited for research; or
4. do not otherwise meet inclusion criteria.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive)	Framed Tobacco Use Message A	Participants will receive two framed messages (AA) plus an incentive
Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive)	Financial Incentive	Participants will receive two framed messages (AA) plus an incentive
Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive)	Framed Introductory Message A	Participants will receive two framed messages (AA) plus an incentive
Arm 2 (Introductory Message A + Tobacco Use Message A)	Framed Introductory Message A	Participants will receive two framed messages (AA)
Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive)	Financial Incentive	Participants will receive two framed messages (AB) plus an incentive
Arm 4 (Introductory Message A + Tobacco Use Message B)	Framed Tobacco Use Message B	Participants will receive two framed messages (AB)
Arm 8 (Introductory Message B + Tobacco Use Message B)	Framed Tobacco Use Message B	Participants will receive two framed messages (BB)
Arm 10 (Introductory Message C + Tobacco Use Message A)	Framed Introductory Message C	Participants will receive two framed message (CA)
Arm 12 (Introductory Message C + Tobacco Use Message B)	Framed Tobacco Use Message B	Participants will receive two framed messages (CB)
Arm 2 (Introductory Message A + Tobacco Use Message A)	Framed Tobacco Use Message A	Participants will receive two framed messages (AA)
Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive)	Framed Tobacco Use Message B	Participants will receive two framed messages (AB) plus an incentive
Arm 4 (Introductory Message A + Tobacco Use Message B)	Framed Introductory Message A	Participants will receive two framed messages (AB)
Arm 6 (Introductory Message B + Tobacco Use Message A)	Framed Introductory Message B	Participants will receive two framed messages (BA)
Arm 6 (Introductory Message B + Tobacco Use Message A)	Framed Tobacco Use Message A	Participants will receive two framed messages (BA)
Arm 10 (Introductory Message C + Tobacco Use Message A)	Framed Tobacco Use Message A	Participants will receive two framed message (CA)
Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive)	Financial Incentive	Participants will receive two framed messages (CB) plus an incentive
Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive)	Framed Introductory Message B	Participants will receive two framed messages (BA) plus an incentive
Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive)	Framed Tobacco Use Message A	Participants will receive two framed messages (BA) plus an incentive
Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive)	Financial Incentive	Participants will receive two framed messages (BA) plus an incentive
Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive)	Framed Tobacco Use Message B	Participants will receive two framed messages (BB) plus an incentive
Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive)	Financial Incentive	Participants will receive two framed messages (BB) plus an incentive
Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)	Framed Introductory Message C	Participants will receive two framed messages (CA) plus an incentive
Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)	Financial Incentive	Participants will receive two framed messages (CA) plus an incentive
Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive)	Framed Introductory Message C	Participants will receive two framed messages (CB) plus an incentive
Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive)	Framed Introductory Message A	Participants will receive two framed messages (AB) plus an incentive
Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive)	Framed Introductory Message B	Participants will receive two framed messages (BB) plus an incentive
Arm 8 (Introductory Message B + Tobacco Use Message B)	Framed Introductory Message B	Participants will receive two framed messages (BB)
Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)	Framed Tobacco Use Message A	Participants will receive two framed messages (CA) plus an incentive
Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive)	Framed Tobacco Use Message B	Participants will receive two framed messages (CB) plus an incentive
Arm 12 (Introductory Message C + Tobacco Use Message B)	Framed Introductory Message C	Participants will receive two framed messages (CB)

Primary Outcome Measures

Name	Time	Method
Full Survey Completion	7 days	The proportion of participants that answers all three survey questions via text message among all those randomized.

Secondary Outcome Measures

Name	Time	Method
Partial Survey Completion	7 days	The proportion of participants that answer at least one of three survey questions via text message among all those randomized.

Trial Locations

Locations (1)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States