Livedoid Vasculopathy: Strong Association With Smoking, Weak Association With Thrombophilia

Completed

• Conditions: Livedoid Vasculitis
• Interventions: Other: Thrombophilia screening

• Registration Number: NCT05878327
• Lead Sponsor: University of Zurich

Brief Summary

A screening of patient histories at the clinics of Dermatology of the universities of Zurich, Basel and Bern is performed in order to identify patients with a history of Livedoid vasculopathy. Patients with a history of livedoid vasculopathy are asked to participate in the study. After reading the patient information and if the informed consent is signed patients are included in the study. Patients are questioned about their smoking history and blood is drawn in order to perform a screening for thrombophilia.

Detailed Description

A screening of patient histories at the clinics of Dermatology of the universities of Zurich, Basel and Bern is performed in order to identify patients with a history of Livedoid vasculopathy. Patients with a history of livedoid vasculopathy are asked to participate in the study. The presence of Livedoid vasculopathy must be confirmed by a histologic specimen. After reading the patient information and if the informed consent is signed patients are included in the study. Patients are questioned about their smoking history and blood is drawn in order to perform a screening for thrombophilia. The presence of a history of smoking and thrombophilia is compared to the general Swiss population.

Study Timeline

• Study Start: 2013-08
• Study First Submitted: 2014-08-03
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Status Verified: 2023-05
• Study First Submitted QC: 2023-05-17
• Last Update Submitted: 2023-05-17
• Study First Posted: 2023-05-26
• Last Update Posted: 2023-05-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• History of livedoid vasculopathy

Exclusion Criteria

• Diagnosis was not proved by biopsy specimen
• A different reason than livedoid vasculopathy has been found for the symptoms of the patient
• No informed consent by the patient

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Thrombophilia screening	Thrombophilia screening	Patients with livedoid vasculopathy. Investigated by thrombophilia screening

Primary Outcome Measures

Name	Time	Method
Smoking history: Patients will be asked if they currently smoke or if they are former smokers. If one of both items is yes, it means a positive answer.	22 months	The primary endpoint is the comparison of a positive smoking history and other cardiovascular risk factors of patients with livedoid vasculopathy with the Swiss general population.

Secondary Outcome Measures

Name	Time	Method
Thrombophilia screening: the following parameters will be determined in every participant: Factor V Leiden, Prothrombin 20210; Protein C, Protein S, Antithrombin III, Beta 2 Glykoprotein 1, Lupus Antikoagulans	22 months	The secondary endpoint is the search for thrombophilia in patients with livedoid vasculopathy.

Trial Locations

Locations (3)

University hospital of Basel; 🇨🇭 Basel, Switzerland

University hospital Zurich; 🇨🇭 Zurich, Switzerland

University hospital of Bern; 🇨🇭 Bern, Switzerland