Change in Daily FeNO During Three Weeks of Inpatient Pulmonary Rehabilitation in Patients with Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Fractional Exhaled Nitric Oxide (FeNO) at rest
研究概览
简要总结
This study investigates the use of fractional exhaled nitric oxide (FeNO) measurement to monitor non-pharmacological therapy during a three-week inpatient rehabilitation programme for asthma patients. It compares FeNO levels (measured three times a day) with clinical parameters and quality of life to analyse daily fluctuations and the acute effect of exercise training on FeNO levels. As FeNO is a non-invasive biomarker of airway inflammation, this study aims to expand its role in therapy monitoring and explore its application in a rehabilitation setting.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •confirmed diagnosis of bronchial asthma (all disease severities)
- •Chronic Obstructive Pulmonary Disease (COPD) with an asthma component, where the asthma component plays a clinically relevant role
- •written informed consent
排除标准
- •Chronic Obstructive Pulmonary Disease (COPD) as the primary disease
- •unability to perform FeNO measurement independently
结局指标
主要结局
Fractional Exhaled Nitric Oxide (FeNO) at rest
时间窗: From enrollment to the end of rehabilitation at 3 weeks. Daily measurements at 9AM; 1PM; 5PM
Measurement of FeNo will be done with the Vivatmo Me device (by Bosch Health Care Solutions GmbH)
Fractional Exhaled Nitric Oxide (FeNO) before/after exercise
时间窗: From enrollment to the end of rehabilitation at 3 weeks, FeNO measurements will be done before and after a bicycle endurance training
Measurement of FeNo will be done with the Vivatmo Me device (by Bosch Health Care Solutions GmbH)
次要结局
- Asthma control(On admission and discharge from the 3-week rehabilitation programme)
- Lung function(On admission and discharge from the 3-week rehabilitation programme)
- Eosinophils(On admission and discharge from the 3-week rehabilitation programme)
- C-reactive protein(On admission and discharge from the 3-week rehabilitation programme)
- Immunoglobulin E (IgE)(On admission and discharge from the 3-week rehabilitation programme)
- 6-minute walk test(On admission and discharge from the 3-week rehabilitation programme)
研究者
Prof. Dr. Andreas Rembert Koczulla
Professor
Schön Klinik Berchtesgadener Land