Treating Thought Problems in Patients With Schizophrenia

Not Applicable

Completed

• Conditions: Schizophrenia
• Interventions: Behavioral: Cognitive Adaptation Therapy (CAT); Behavioral: Minimal Environmental Supports (MES)

• Registration Number: NCT00051740
• Lead Sponsor: The University of Texas Health Science Center at San Antonio

Brief Summary

This study will compare Cognitive Adaptation Training (CAT) to minimal schizophrenia treatment. This study will also determine whether the intensity of CAT can be reduced and still provide benefits to patients with schizophrenia.

Detailed Description

Many schizophrenia patients have serious difficulties that affect their quality of life. Cognitive Adaptation Training (CAT) may improve adaptive functioning, quality of life, and rates of relapse in schizophrenia patients. CAT, which involves compensatory strategies or environmental supports, is tailored to each individual and is based on executive functioning levels and other factors.

Participants are randomly assigned to CAT, Minimal Environmental Supports (MES), or treatment as usual for 2 years. Participants receiving CAT will have a trained therapist make weekly visits to their home for 9 months. Over the following 3 months, the frequency of CAT visits will be slowly reduced to once a month. For the remaining 12 months of treatment, patients receive CAT only once a month.

Participants assigned to the MES group receive a generic set of supplies and equipment (calendar, alarm clock, watch, bus passes, etc.) at the beginning of the 2-year period. Each month, the supplies are replenished as necessary during the patient's scheduled clinic visit.

In all groups, assessments of adaptive function and quality of life occur at study start and at 3, 6, 9, 18, and 24 months.

Study Timeline

• Study Start: 2002-02
• Study First Submitted: 2003-01-15
• Study First Submitted QC: 2003-01-16
• Study First Posted: 2003-01-17
• Primary Completion: 2008-10
• Study Completion: 2008-10
• Status Verified: 2013-04
• Last Update Submitted: 2013-04-05
• Last Update Posted: 2013-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• DSM-IV diagnosis of schizophrenia or schizoaffective disorder
• Treatment with an atypical antipsychotic medication
• Stable living environment
• Able to read, understand, and complete rating scales and neuropsychological testing
• Willing to participate in psychosocial treatments for schizophrenia that may involve home visits

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Exclusion Criteria

• History of significant head trauma, seizure disorder, or mental retardation
• Alcohol or drug abuse that could interfere with participation in the study
• Treatment by an ACT team
• History of violence in the past year
• Score > 80 on the SOFAS
• Hospitalized in the past year

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cognitive Adaptation Therapy	Cognitive Adaptation Therapy (CAT)	Subjects receive Cognitive adaptation therapy as part of treatment for schizophrenia
Minimal Environmental Support	Minimal Environmental Supports (MES)	Subjects receive minimal environmental support in schizophrenia treatment

Primary Outcome Measures

Name	Time	Method
Primary	up to 24 months	compare Cognitive Adaptation Training (CAT) to minimal schizophrenia treatment.

Trial Locations

Locations (1)

University of Texas Health Science Center at San Antonio; 🇺🇸 San Antonio, Texas, United States