Determination of Thresholds in Early Coagulopathy in Trauma
Recruiting
- Conditions
- D65.1
- Registration Number
- DRKS00015886
- Lead Sponsor
- Bundesministerium für Verteidigung / Sanitätsakademie der Bundeswehr / Wehrmedizinische Sonderforschung / Abteilung EProjekt ID:
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
inclusion criteria (AND)
- Trauma history and
- Patient age >= 18 years
- actual or suspected acute bleeding situation and / or existing circulatory instability
Exclusion Criteria
Exclusion criteria (OR)
- severe hypothermia <30 ° C possibly subsequent exclusion
- pregnant patients
- Anticoagulated patients (vitamin K antagonists, NOAKs and other) except ASS or clopidogrel.
- pre-existing acquired or hereditary thrombophilia or coagulopathy
- Tranexamic acid administration before prehospital blood sampling
- Refusal of the patient to participate in clinical trials
A subsequent exclusion takes place in the event of later disclosure of the existence of exclusion criteria.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary goal is to check a threshold value of -6mmol/L for the detection of early trauma-induced coagulopathy in the trauma patient with actual or suspected bleeding and / or existing circulatory instability (time T0 = emergency department and T1 = emergency room)<br><br>Target parameters: Preclinical and in-clinic BaseExcess, Clotting Time (CT) lengthened, Clot Formation Time (CFT) extended, Clot Firmness (CF) A10 (Amplitude 10 min after CT) and MCF (Maximum Clot Firmness) after 30 min decreases in EXTEM and FIBTEM of thrombelastometry.<br>
- Secondary Outcome Measures
Name Time Method