Whole clotting assessment as predictor of clinical phenotype in aged patients with haemophilia A

Withdrawn

• Conditions: haemophilia; 10064477

• Registration Number: NL-OMON37558
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

- male;
- patients aged > 60 years with haemophilia A;
- patients aged between 20-30 years with haemophialia A;
- patients known at the Haemophilia Center of the Academic Medical Center;
- patients who visit the Haemophilia Center for routine blood testing (inhibitor testing);
- patients whose age of first bleeding and bleeding frequency have been recorded;
- only if written informed consent from patient is given.

Exclusion Criteria

- patients with an inhibitor in the past;
- administration FVIII concentrate < 72 hours prior to blood sampling;
- acquired coagulation disorders by hepatic dysfunction;
- usage of ASA or NSAID.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Clinical parameters:<br /><br>- age of first bleeding,<br /><br>- extent of arthropathy<br /><br><br /><br>Laboratory parameters:<br /><br>- result ETP/TM-ETP (lag time, peak thrombin, area under the curve)<br /><br>- result T-TAS (time to occlusion, occlusion time, occlusion speed, area under<br /><br>the curve)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.v.t.</p><br>