Whole clotting assessment as predictor of clinical phenotype in patients with severe haemophilia A
Completed
- Conditions
- 10064477haemophilia
- Registration Number
- NL-OMON35637
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 14
Inclusion Criteria
male
patients with severe haemophilia A (FVIII <0.01 IU/mL)
patient aged 5 to 25 years
patient with first bleeding at least 5 years ago
patient known at the Haemophilia Treatment Center of the Academic Medical Center
patient who visit the Haemophilia Treatment Center for routine blood testing (inhibitor testing)
patient whose age of first bleeding and bleeding data have been recorded
written informed consent from patient or in minors from parents/guardians is given
Exclusion Criteria
patient with inhibitor in the past
administration FVIII concentrate < 72 hours prior to blood sampling
acquired coagulation disorders by hepatic dysfunction
use of ASA or NSAID's
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Clinical parameters: age of first bleeding, clinical bleeding score<br /><br>Laboratory parameters: whole clotting assessment parameters (TM-ETP/ETP: lag<br /><br>time, peak thrombin, area under the curve. T-TAS: time to occlusion, occlusion<br /><br>time, occlusion speed, area under the curve)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>