Multimodal Investigation of Neural Plasticity
- Conditions
- Mild Cognitive Impairment
- Interventions
- Device: active tDCSDevice: sham tDCS
- Registration Number
- NCT06453980
- Lead Sponsor
- University of Michigan
- Brief Summary
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).
- Detailed Description
The goal of this study is to learn important information about the effects of weak electrical stimulation (known as high-definition transcranial direct current stimulation or HD-tDCS) on brain functioning in those with mild cognitive impairment (MCI). The findings will help determine how stimulation affects brain's activity and metabolism (in particular, the neurotransmitter glutamate). Ultimately, this information may help develop new treatments for those with Alzheimer's disease. The study will use different forms of brain imaging to see whether stimulation changes how the brain responds during a memory task. Functional magnetic resonance spectroscopy (fMRS), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS) will be used. The study also uses cognitive tests and questionnaires.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 80
- Normal cognition for HC and diagnosis of Mild Cognitive Impairment (MCI) for MCI participants
- Right-handedness
- Magnetic resonance compatible, criteria that also apply for high definition transcranial direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants in the upper body or head)
- History of other contributing neurological or medical conditions known to affect cognitive functioning
- Significant mental illness
- Sensory impairments that limit ability to participate
- History of alcohol or drug abuse/dependence
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description HC active tDCS active tDCS 3 milliAmp dose of HD-tDCS treatment for 20 minutes, for 1 session. HC sham tDCS sham tDCS Sham (placebo) dose of HD-tDCS treatment for 20 minutes, for 1 session. MCI sham tDCS sham tDCS Sham (placebo) dose of HD-tDCS treatment for 20 minutes, for 1 session. MCI active tDCS active tDCS 3 milliAmp dose of HD-tDCS treatment for 20 minutes, for 1 session.
- Primary Outcome Measures
Name Time Method Changes in glutamate concentration (fMRS) average on 1 week Analyses via fMRS using units of concentration
Changes in brain activation (fMRI) average of 1 week Analyses via fMRI using units of brain activation
- Secondary Outcome Measures
Name Time Method Changes in memory performance average of 1 week Analyses of memory performance indexed as percent accuracy
Changes in brain activation (fNIRS) immediate, concurrent with tDCS Analyses via fNIRS using units of brain activation
Trial Locations
- Locations (1)
University of Michigan
🇺🇸Ann Arbor, Michigan, United States