TCTR20210706003
Not yet recruiting
Not Applicable
Comparison of 28-days mortality rate in patients with cardiogenic shock receiving between norepinephrine and dopamine.
Faculty of Pharmaceutical Sciences, Chulalongkorn University0 sites476 target enrollmentJuly 6, 2021
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Patients with cardiogenic shock require vasopressor agents or inotrope agents to restore and maintain blood pressure and cardiac output.
- Sponsor
- Faculty of Pharmaceutical Sciences, Chulalongkorn University
- Enrollment
- 476
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with cardiogenic shock who admitted to the CCU and ICCU at King Chulalongkorn Memorial Hospital between 1 January 2014 to 31 December 2021\.
- •All adults patients age greater than 18 who receieved norepinephrine or dopamine. Patients diagnosed with cardiogenic shock were identified by the presence of International Classification of Disease, tenth revision, ICD 10th code R570 in the list of diagnosed generated during the course of their hospital stay or identified by clinical criteria (SBP\< 90 mmHg despite adequate amount of fluids had been administration and if there were signs of tissue hypoperfusion (e.g. altered mental state, cold extremities, urine output of \< 0\.5 ml/kg/h or \< 30 ml/h, arterial blood pH \< 7\.35, arterial blood lactate \> 2 mmol/L or serum creatinine rising at least 0\.3 mg/dL or increasing more than 1\.5 to 1\.9 times of baseline serum creatinine) or hemodynamic criteria (e.g. cardiac index less than 2\.2 L/min/m2 and pulmonary capillary wedge pressure more than 15 mmHg) in 24 to 48 hours before received norepinephrine or dopamine.
Exclusion Criteria
- •1\. Shock from other cause such as hypovolemic shock, sepsis shock or anaphalaxis shock in 24 to 48 hours before received norepinephrine or dopamine.
- •2\. Patients with cardiogenic shock who recieved both norepinephrine and dopamine.
Outcomes
Primary Outcomes
Not specified
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