NCT05589584已完成3 期
Effect of N-acetyl Cysteine on Markers of Oxidative Stress and Insulin Resistance in Patients with Non-alcoholic Fatty Liver Disease
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- assessment of the effect of NAC on leptin
研究概览
简要总结
Effect of N-acetyl cysteine on markers of oxidative stress and insulin resistance in patients with Non-alcoholic fatty liver disease
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males or females aged 18-60 years diagnosed with NAFLD
排除标准
- •History of alcohol consumption, drug addiction or the use of medications known to precipitate steatohepatitis.
- •Patients with schistosomiasis, active hepatitis B or C, autoimmune and diabetes mellitus.
- •current Consumption of any antioxidant supplements and hepatotoxic drug.
- •Pregnancy or lactation or expecting to get pregnant during the study.
- •Medical, psychological, or pharmacological factors interfering with the collection or interpretation of study data.
- •Active Cancer patients.
- •Anyone having hypersensitivity to N-acetylcysteine.
- •Anyone already taking N-acetylcysteine.
研究组 & 干预措施
intervention
Experimental
NAC and weight reduction program
干预措施: N acetyl cysteine with weight reduction (Drug)
结局指标
主要结局
assessment of the effect of NAC on leptin
时间窗: 3 months
leptin as insulin resistance marker in NAFLD
次要结局
- assessment of the effect of NAC on MDA(3 months)
研究者
Asmaa Mohammad Ramadan
hospital pharmacist
Ain Shams University
研究点 (1)
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