What is the effect of inhalational anaesthetic agents on blood glucose levels in non diabetic patients?

Completed

Brief Summary: The study will be conducted to observe the effects of Sevoflurane, Isoflurane and Desflurane on blood glucose levels in non-diabetic patients. Very few research articles are available on this study and hence the results obtained from this study will be useful in choosing the appropriate inhalational agent in patients and can help in achieving better glycemic control.The results obtained will also be a useful research tool for further studies in diabetic patients.

Recruitment & Eligibility

Inclusion Criteria

1.Age: 18 to 60 years 2.Gender: both male and female 3.ASA grade: I or II 4.Duration of surgery : Minimum 2 hours.

Exclusion Criteria

1.Patient refusal 2.Diabetic patient/ hyperglycemic patient 3.Hypertensive patient 4.Patient on drugs causing hypo or hyperglycemia like steroids, OHA, etc.
5.Contraindication to inhalational anesthetic agents- Uncontrolled hypotension, previous history of malignant hyperthermia, increased intracranial pressure 6.Patient requiring Rapid sequence intubation 7.Patients with pancreatic disorders such as chronic pancreatitis, carcinoma pancreas, etc 8.Patients with Catecholamine secreting tumors 9.Patients undergoing pancreatic surgeries.

Primary Outcome Measures

Name	Time	Method
Blood glucose levels	baseline, preinduction, at MAC 1, at 15 minute intervals intraoperatively, AFter achieving MAC 0, Postoperative

Secondary Outcome Measures

Name	Time	Method
Best inhalational agent with respect to glycemic control	Blood glucose at baseline, preinduction, at MAC 1, at 15 minute intervals intraoperatively, AFter achieving MAC 0, Postoperative

Locations (1): All India Institute of Medical Sciences, Raipur
🇮🇳
Raipur, CHHATTISGARH, India
All India Institute of Medical Sciences, Raipur
🇮🇳Raipur, CHHATTISGARH, India
Dr Chandini K
Principal investigator
9361419889
chandiniamar01@gmail.com