MedPath

Bioavailability of Pea Protein in Young and Old Volunteers

Not Applicable
Completed
Conditions
Healthy Male Volunteers
Interventions
Dietary Supplement: Pea protein (NUTRALYS ® S85 plus) in water
Dietary Supplement: Pea protein (NUTRALYS ® S85 plus) within meal
Dietary Supplement: Whey protein in water
Dietary Supplement: Whey protein within meal
Registration Number
NCT06381869
Lead Sponsor
Roquette Freres
Brief Summary

The aim of this study done in healthy, non-malnourished young and elderly subjects, is to measure the bioavailability of protein intake and the variation of metabolic markers following consumption of pea protein " NUTRALYS ® S85 plus" or a reference protein brought in water either alone or at the end of a standardized meal.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
Male
Target Recruitment
30
Inclusion Criteria
  • Adult male volunteers, aged over 65 or under 30
  • Body mass index (weight in kg/ height² in m²) between 22 and 28 kg/m²,
  • Subjects considered to be healthy by the principal investigator doctor according to the interview, medical and clinical examination,
  • Biological assessment considered compatible with participation in the study,
  • Persons able to sign the informed consent,
  • Persons affiliated to social security scheme.
Exclusion Criteria
  • Pathologies or treatments not compatible with the study
  • Food allergy or a contraindication to the consumption of the products tested
  • Subject in a situation which, in the opinion of the investigator, could interfere with their optimal participation in the study or constitute a particular risk for the subject,
  • Subject with a particular diet (vegetarians, vegans, nutritional supplements, etc.),
  • Subject weighing < 55 kg,

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
Young volunteersPea protein (NUTRALYS ® S85 plus) in waterVolunteers under 30 years old
Elderly volunteersPea protein (NUTRALYS ® S85 plus) within mealVolunteers over 65 years old.
Young volunteersWhey protein in waterVolunteers under 30 years old
Young volunteersPea protein (NUTRALYS ® S85 plus) within mealVolunteers under 30 years old
Young volunteersWhey protein within mealVolunteers under 30 years old
Elderly volunteersPea protein (NUTRALYS ® S85 plus) in waterVolunteers over 65 years old.
Elderly volunteersWhey protein in waterVolunteers over 65 years old.
Elderly volunteersWhey protein within mealVolunteers over 65 years old.
Primary Outcome Measures
NameTimeMethod
Leucine blood concentration0 minute before eating the test meals, then regularly until 360 minutes after ingestion.
Secondary Outcome Measures
NameTimeMethod
Essential amino acids blood concentration (µmol/L)0 minute before eating the test meals, then regularly until 360 minutes after ingestion.
Non essential amino acid blood concentration (µmol/L)0 minute before eating the test meals, then regularly until 360 minutes after ingestion.
Blood glucose concentration (g/L)0 minute before eating the test meals, then regularly until 360 minutes after ingestion.
Blood insulin concentration (μIU/ml)0 minute before eating the test meals, then regularly until 360 minutes after ingestion.
Blood lipid profile (glycerol concentration in mg/l and non-esterified fatty acids concentration in mg/l)0 minute before eating the test meals, then regularly until 360 minutes after ingestion.
Blood inflammatory profile (TNF-α blood concentration in pg/ml and IL-6 blood concentration in pg/ml)0 minute before eating the test meals, then regularly until 360 minutes after ingestion.

Trial Locations

Locations (1)

Unité d'Exploration en Nutrition Centre de Recherche en Nutrition Humaine d'Auvergne

🇫🇷

Clermont-Ferrand, France

© Copyright 2025. All Rights Reserved by MedPath