Daily Activity After Corticosteroids Injection Among Knee Osteoarthritis Patients

Phase 4

Completed

• Conditions: Knee Osteoarthritis
• Interventions: Drug: Corticosteroids injection

• Registration Number: NCT02049879
• Lead Sponsor: Laval University

Brief Summary

The objective of this study was to objectively measure daily physical activity and spatiotemporal gait pattern, as well as improvements in self reported symptoms and quality of life, before and six weeks after an intra-articular corticosteroids injection in patients suffering from knee osteoarthritis. Fourteen patients with unilateral knee osteoarthritis were recruited. The intra-articular corticosteroid injection was given at the end of the second week. Physical activity was objectively measured by an accelerometer worn by the participants for eight weeks. In addition, the Western Ontario and McMaster Universities Arthritis Index (WOMAC), the Medical Outcome Study Short Form-36 (MOS-SF36) and gait trials were completed every two weeks to assess symptoms, quality of life and spatiotemporal parameters of gait.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-11
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Study First Submitted: 2014-01-28
• Study First Submitted QC: 2014-01-29
• Study First Posted: 2014-01-30
• Status Verified: 2014-02
• Last Update Submitted: 2014-02-28
• Last Update Posted: 2014-03-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• 50 years old or more
• Medial knee osteoarthritis (Kellgren & Lawrence Grade I to III)

Exclusion Criteria

• Intra-articular injection during the last six months
• Isolated femoro-patellar arthritis
• Rheumatoid arthritis
• Knee instability
• Spinal stenosis
• Lower limb fracture over the last year
• Lower limb surgery in the last three months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Injection	Corticosteroids injection	Corticosteroids injection

Primary Outcome Measures

Name	Time	Method
Change in Knee pain	Change from Baseline at 2, 4 and 6 weeks
Change in physical activity	Change from baseline at 2, 4 and 6 weeks

Secondary Outcome Measures

Name	Time	Method
Change in function and quality of life	Change from baseline at 2, 4 and 6 weeks	Assessment with WOMAC and MOS-SF36 questionnaires
Change in Spatiotemporal gait parameters	Change from Baseline at 2, 4 and 6 weeks	Gait symmetry was verified with regards to the swing and stance phase durations and step length

Trial Locations

Locations (1)

Pavillon de l'Éducation Physique et des Sports - Université Laval; 🇨🇦 Quebec, Canada