nderstanding Extracorporal Membrane Oxygenation Induced Coaguloapathy – A Prospective Cohort Study in the Intensive Care Unit (EXTRICATE) - EXTRICATE

niversität Witten/Herdecke & Klinik Köln Merheim0 sites50 target enrollmentFebruary 29, 2024

Overview

No summary available.

Registry

who.int

Start Date

February 29, 2024

End Date

TBD

Last Updated

last year

Study Type

Observational

Sex

All

Sponsor

niversität Witten/Herdecke & Klinik Köln Merheim

•For VV\-ECMO analogous to previous studies:
•\- severe ARDS according to the Berlin criteria
•\- PaO2:FiO2 ratio \<50 mmHg for \>3 hours despite optimization of mechanical ventilation \[FiO2 \=80%, tidal volume \= 6 ml per kg of ideal body weight and positive end\-expiratory pressure (PEEP) \=10 cm H2O) and despite the use of adjuvant therapeutic measures (e.g. inhaled nitric oxide therapy, recruitment maneuver, ventilation in prone position)]
•\- PaO2:FIO2 ratio \<80 mmHg for \>6 hours despite the aforementioned measures
•\- Arterial pH \<7\.25 with PaCO2 \>60 mmHg for \>6 hours under ventilator settings with a plateau pressure \=32 cm H2O
•For VA\-ECMO analogous to previous studies:
•\- Observed collapse with no\-flow time \< 5 min and low\-flow time \< 90 min on arrival in the cardiac catheter
•\- Initial and sustained defibrillable rhythm or non\-defibrillable rhythm in case of tamponade or pulmonary artery embolism (exception: accidental hypothermia or intoxication)

•1\. pregnancy
•2\. patient moribund or with Simplified Acute Physiology Score value \>90
•3\. underlying malignancy with life expectancy \< 5 years
•4\. irreversible neurological damage
•5\. decision to limit therapy
•6\. ventilation for longer than 7 days (for vv\-ECMO)
•7\. chronic lung disease and chronic respiratory respiratory insufficiency with home oxygen therapy (for vv\-ECMO)
•8\. history of heparin\-induced thrombocytopenia or other contraindication to heparin
•9\. hereditary thrombophilia or hemophilia
•10\. therapeutic anticoagulation or dual platelet inhibition