Dexmedetomidine versus propofol on intestinal barrier function in patients undergoing major gastrointestinal tract surgery: A prospective randomized comparative trial
Phase 4
- Conditions
- Major gastrointestinal surgeryDexmedetomidine, Propofol, Major gastrointestinal surgery, Intestinal barrier function, D-lactate, Randomized
- Registration Number
- TCTR20230118002
- Lead Sponsor
- Medicine faculty, King Chulalongkorn memorial hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 58
Inclusion Criteria
1. Age more than 18 years old and under 80 years old
2. Elective case for major GI surgery
3. Tracheal intubation and mechanical ventilation at least 12 hrs in ICU admission
4. Epidural Analgesia
Exclusion Criteria
1. Pregnancy and breast feeding
2. Organ or bone marrow Transplants
3.Delirium or dementia
4.Cerebrovascular accident
5. High grade atrioventricular blocks without cardiac pacemaker
6. Acute liver failure
7.contraindications for epidural analgesia
8. Allergy to propofol or dexmedetomidine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method D-lactate dehydrogenase 0,12,24 hrs at the beginning of study colorimetric
- Secondary Outcome Measures
Name Time Method Time to first defecation at the beginning of study hours