Goal-directed vs. Empirical Tranexamic Acid Administration in Cardiovascular Surgery
Not Applicable
- Conditions
- Diseases of the circulatory system
- Registration Number
- KCT0008419
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 764
Inclusion Criteria
1)Those who are 19 years of age or older
2)Patients who will undergo elective cardiovascular surgery employing cardiopulmonary bypass
3) Patients who provide written informed consent
Exclusion Criteria
1)pregnancy
2)refusal of allogenic blood transfusion
3)taking thrombin
4)history of thromboembolic and familial hypercoagulability disease
5)recent history of myocardial infarction or ischemic cerebral infarction (within 90 days)
6)hypersensitive to TXA
7)histroy of convulsion or epilepsy
8)taking hemodialysis
9)history of Heparin-induced thrombocytopenia
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method postoperative bleeding
- Secondary Outcome Measures
Name Time Method postoperative transfusion amount;postoperative transfusion rate;the lowest postoperative hemoglobin value;reoperation due to postoperative bleeding;Coagulation function test (Hemogalobin, PT-INR, aPTT, fibrinogen, platelet, D-dimer ROTEM);Seizures;delirium;mortality;thromboembolic complication (myocardial infarction, stroke, pulmonary embolism, gut infarction);Acute kidney injury;Renal replacement therapy;Mechanical assistance devices;duration of mechanical ventilation;length of stay in ICU and hospital;Total cost (including seizure related)