Clinical observation for multiple use of tranexamic acid after total knee arthroplasty

Not Applicable

Recruiting

• Conditions: Total knee arthroplasty

• Registration Number: ITMCTR1900002300
• Lead Sponsor: Guanghua Hospital, Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1) The primary unilateral total knee arthroplasty is required for the end stage of primary OA or RA;
2) Aged 55-80 years old;
3) perioperative patients receiving tranexamic acid antifibrinolytic therapy;
4) Preoperative hemoglobin, normal coagulation function.

Exclusion Criteria

1) Patients with secondary osteoarthritis other than primary knee osteoarthritis or rheumatoid arthritis (eg post-traumatic osteoarthritis, gouty osteoarthritis, hemophilic osteoarthritis, tuberculosis, Arthritis, ankylosing spondylitis, etc.);
2) Primary OA or RA requiring bilateral total knee arthroplasty;
3) suffering from severe cardiovascular diseases (such as myocardial infarction, atrial fibrillation, angina pectoris, heart failure, etc.), cerebrovascular diseases (cerebral infarction, cerebral hemorrhage, etc.), requiring long-term oral anticoagulant drugs (such as aspirin, warfarin) , clopidogrel, etc.);
4) Diagnosis of hemophilia or coagulopathy.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hematocrit;Hemoglobin;