Clinical observation of multiple dose use of tranexamic acid in patients with rheumatoid arthritis after total knee arthroplasty

Phase 4

Recruiting

• Conditions: Total knee arthroplasty

• Registration Number: ITMCTR1900002510
• Lead Sponsor: Guanghua Hospital, Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Diagnosed as rheumatoid arthritis according to the Classification of Rheumatoid Arthritis revised by the American College of Rheumatology in 1978 and the classification of rheumatoid arthritis by the American College of Rheumatology and the European Union of Rheumatology in 2010. Kellgren-LawrenceX line is graded III or IV;
2. Aged 50-75 years;
3. Initial unilateral TKA surgery;
4. Perioperative TXA antifibrinolytic therapy;
5. Preoperative hemoglobin, The coagulation function is normal.

Exclusion Criteria

1. With severe cardiovascular disease (such as myocardial infarction, atrial fibrillation, angina pectoris, heart failure, etc.), cerebrovascular disease (cerebral infarction, brain Bleeding, etc., need long-term oral anticoagulant drugs (such as aspirin, warfarin, clopidogrel, etc.).

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hemoglobin;