To Analyse Changes in the Levels of Salivary Lysozyme in Partially Edentulous Patients Before and After Removable Prosthetic Treatment among

Completed

• Conditions: Factors influencing health status and contact with health services, (2) ICD-10 Condition: K084||Partial loss of teeth,

• Registration Number: CTRI/2021/04/032899
• Lead Sponsor: DrShefali Dogra

Brief Summary

The useof this study helps to analyse the relationship and association of thesesalivary biomarkers which are entities within the body capable of providing impartialinformation regarding the current physiologic state of a living organism beforeand after comprehensive dental treatment in partially edentulous patients.

There area very limited studies on the relationship of salivary lysozymeconcentrations with partially edentulous patients.

Thisstudy helps to monitor the health and disease status  through an oral biofluid, salivaas a credible diagnostic tool. Â§Thisstudy helps in understanding the role and importance of saliva in the field of Prosthodontics.

To studythe alterations in their concentration that can beassociated with the onset, progression, or even regression of a particulardisorder and could not only provide information concerning disease pathogenesisand progression but also support their position as evaluators of health.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-16
• Study Completion: 2021-10-22
• Last Update Posted: 2022-03-02

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients having partially edentulous arches with more than 3 and less than 6.
• Age group between 35-60 years.
• Patients who are non-smokers.
• Patients wearing dentures for the first time.

Exclusion Criteria

• Patients with very poor oral hygiene having OHI-S score between 3.1-6.0. Patients taking any kind of medications which may affect salivary secretions from last 3 months.
• Pregnant and lactating females.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To find correlation between concentrations of Lysozyme before i.e. baseline and after three months after insertion of removable partial denture in successive samples of unstimulated saliva collected from partially edentulous patients.	The study is conducted at baseline i.e. at 0 months and after 3 months of denture insertion.

Secondary Outcome Measures

Name	Time	Method
To compare the changes in the level of salivary lysozyme before and after the RPD insertion	3 months

Trial Locations

Locations (1)

Manav Rachna DentalCollege; 🇮🇳 Faridabad, HARYANA, India

Manav Rachna DentalCollege

🇮🇳Faridabad, HARYANA, India

Dr Shefali Dogra

Principal investigator

9805215461

sdogra94@yahoo.in