Imaging vascularisation and morphometry in burns and scars by Optical Coherence Tomography

Completed

Conditions: 1. Vascularisation en morphometry of burns and scars 2. Imaging of blood flow and tissue structure
10014982

Registration Number: NL-OMON40457

Lead Sponsor: Brandwondencentrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 10

Inclusion Criteria

Age > 18 years
Competent or temporary incompetent (because of sedation and/or intubation)
Acute burn wound and a planned operation of the burn wound or:
Burn scar and an already planned excision (operation) of the scar

Exclusion Criteria

Language barrier
Pre-existing vascular problems both acquired (venous or arterial diseases) or congenital (such
as vascular malformations)
(Possible) pregnancy

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the utility of OCT to perform objective assessment<br /><br>of the vascularisation and surrounding tissue in burns and scars. Based on<br /><br>previous studies we expect to see a loss of layered structure in (deep) burn<br /><br>wounds and reduced to absent vascularisation. Moreover, a smaller birefringence<br /><br>and collagen denaturation can be found in thermally injured skin. To quantify<br /><br>the vascularisation in scars, we endeavour to identify the diameter of blood<br /><br>vessels and obtain vessel density . </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Scar: colour, elasticity, subjective scar outcome assessed by the POSAS.<br /><br>- Burn wound: depth assessment by the clinical impression of an experienced<br /><br>burn clinician.<br /><br><br /><br>The secondary study parameters are not used for determination of the utility of<br /><br>OCT but may be used to perform additional analyses.<br /><br>E.g.: assessing agreement between colour measurement and vessel density<br /><br>assessed by OCT.</p><br>