Vessel wall imaging in moymoya vasculopathy using intracranial MRI at 7.0 tesla

Completed

Conditions: moyamoya
puff of smoke
10007963
10003216

Registration Number: NL-OMON47058

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Inclusion criteria for pediatric patients
- Moyamoya vasculopathy
- Signed informed consent
- Age 12-18 yrs old
- MRI without anesthesia;Inclusion criteria for adult patients
- Moyamoya vasculopathy
- Signed informed consent
- Age 18-55 yrs old
- Legally competent
- MRI without anesthesia;Inclusion criteria for control subjects
- 12-60yrs old
- 7T MR imaging performed for suspected pituitary adenoma
- No known intracranial vessel wall disease or history of cerebrovascular events
If applicable:
- Legally competent
- Signed informed consent
- MRI without anesthesia

Exclusion Criteria

For patients
- Allergic to gadolinium
- Impaired renal function (severe renal insufficiency, GFR <30ml/min/1.73m2, or nephrogenic systemis fibrosis/ nephrogenic fibrosing nephropathy (NSF/NFG))
- Impossibliity to undergo MRI (claustrophobia, implants or metal objects in or around the body)
- Pregnancy;For control subjects
- Allergic to gadolinium
- Impaired renal function (severe renal insufficiency, GFR <30ml/min/1.73m2, or nephrogenic systemis fibrosis/ nephrogenic fibrosing nephropathy (NSF/NFG))
- Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body)
- Pregnancy
- Previous history of cerebrovascular diseases

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The intracranial vessel wall (circle of Willis and its main branches and the<br /><br>moyamoya vessels) characteristics in MMV.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters/endpoints<br /><br>Establishing differences (e.g. in presence or absence of intracranial vessel<br /><br>wall abnormalities) in the vessel walls between the symptomatic and<br /><br>asymptomatic hemisphere in each individual patient and between children and<br /><br>adults.<br /><br><br /><br>Third study parameters/endpoints<br /><br>The investigation of blood flow through the major arteries (circle of Willis<br /><br>and its main branches) and the moyamoya vessels (lenticulostriatal and<br /><br>leptomeningeal collaterals).<br /><br><br /><br>Other study parameters<br /><br>The characterization the intracranial vessel wall, by evaluating the signal<br /><br>characteristics on multiple MRI sequences.</p><br>