MR Intracranial Vessel wall Imaging in ischemic stroke patients, TIA patients and controls

Withdrawn

Conditions: Vessel wall atheroma
artery hardening
10007963
10003216

Registration Number: NL-OMON32985

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 180

Inclusion Criteria

Main inclusion criteria for stroke patients and TIA patients:
• 18 years or older
• Male or female
• Ready for MRI scanning within 1 week after onset of ischemic symptoms;Additional inclusion criteria for stroke patients:
• Ischemic symptoms conform PACI/TACI (Partial/Total Anterior Circulation Infarct)
• CT acute stroke imaging protocol: area of ischemia of the cerebral anterior perfusion territory based either on anatomical CT images or on CT perfusion images;Additional inclusion criteria for TIA patients:
• Transient ischemic symptoms (< 24 hours of duration) conform PACS/TACS (Partial/Total Anterior Circulation Syndrome)
• No area of ischemia visualized on either anatomical CT images or on CT perfusion images

Exclusion Criteria

• Stroke patients with either a hyperdense vessel sign on CT or occlusion of an artery of the anterior cerebral circulation on CT angiography, but not both or neither
• Patients with a known cardiac cause of stroke
• Patients with a stroke secondary to surgical / interventional procedures
• Allergic reaction to gadolinium
• Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our main study parameter is the presence or absence of intracranial<br /><br>atherosclerosis in one (or more) arteries of the anterior cerebral circulation<br /><br>in the aforementioned groups.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are signal characteristics of the intracranial<br /><br>vessel wall atheroma on multiple MRI-sequences and two different magnetic field<br /><br>strengths, combined with histology as golden standard if applicable. Our<br /><br>(secondary) outcome will be cognitive functioning of the subject, in<br /><br>association with possible microvascular damage.</p><br>