Intracranial vessel wall MR imaging at 3.0 and 7.0 tesla in patients with TIA or ischemic stroke of the posterior circulatio

Completed

Conditions: atherosclerosis
hardening of the arteries
10003216
10007963

Registration Number: NL-OMON47288

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

>= 18 years of age;Additional inclusion criteria for ischemic stroke / TIA patients:
- TIA or ischemic stroke in the posterior circulation territory (= supplied via the vertebral and basilar arteries or their branches)
- Possibility to perform MRI scanning within 3 months after onset of relevant ischemic symptoms

Exclusion Criteria

- Allergic reaction to gadolinium or one of the constituents of its solution for administration
- Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body)
- Severely impaired renal function (severe renal insufficiency, GFR < 30ml/min/1,73m2; or nephrogenic systemic fibrosis / nephrogenic fibrosing nephropathy (NSF/NFD))
- Pregnancy;Additional exclusion criteria for ischemic stroke / TIA patients:
- A TIA or ischemic stroke secondary to a surgical or interventional procedure
- Previous vertebrobasilar surgery or endovascular therapy

Additional exclusion criteria for healthy volunteers:
- History of cerebral events (e.g. ischemic stroke, TIA, hemorrhage)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The presence or absence of intracranial vessel wall abnormalities in arteries<br /><br>of the intracranial posterior circulation. Presence of atherosclerosis is<br /><br>defined as any irregularity of the arterial vessel wall.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Number of vessel wall abnormalities in the intracranial vessel wall MRI scan<br /><br>at 7.0 tesla as compared to 3.0 tesla.<br /><br>- Characteristics of intracranial vessel wall atheroma, by discriminating<br /><br>different MRI signal intensities in the vessel wall atheroma.<br /><br>- The clinical outcome measures (e.g. occurrence of vascular events, level of<br /><br>handicap, current medication) collected during follow-up.</p><br>