on-invasive MR imaging of vulnerable carotid artery plaque characteristics

Completed

• Conditions: arteriosclerosis; atherosclerotic plaque; inflammation in the vessel wall; 10003216

• Registration Number: NL-OMON49132
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

* Patients only: Known with an atherosclerotic lesion in (one of) the carotid
arteries of at least 2 mm thick causing 30-99% stenosis [ECST guideline
* Healthy volunteer only: Should consider himself/herself as 'healthy' and not
known with any major cardiovascular diseases

Exclusion Criteria

* 100% stenosis (total occlusion)
* MRI contraindications

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess reproducibility of the new MRI techniques acquiring carotid artery<br /><br>plaque deformation during the cardiac cycle.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To correlate plaque deformation with plaque components that are most likely<br /><br>apparent in (vulnerable) atherosclerotic plaques (e.g. lipid-rich necrotic<br /><br>core, fibrous cap, calcifications and fibrous tissue)</p><br>