Diagnosing cerebral vasculitis using MR intracranial vessel wall imaging at 7.0 tesla

Completed

• Conditions: cerebral vasculitis; vessel wall inflammation; 10007963; 10047066

• Registration Number: NL-OMON47118
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Inclusion criteria for healthy volunteers
- 18 years or older;Inclusion criteria for patients
- 18 years or older
- Ready for MRI before starting treatment of cerebral vasculitis(is applicable)
- Suspected cerebral vasculitis

Exclusion Criteria

Exclusion criteria for healthy volunteers
- Allergic reaction to gadolinium
- Impaired renal function (severe renal insufficiency, GFR
<30ml/min/1,73m2; or nephrogenic systemic fibrosis/ nephrogenic fibrosing
nephropathy (NSF/NFG))
- Impossibility to undergo MRI (claustrophobia, implants or metal objects in
or around the body)
- Pregnancy
- Previous history of cerebral vasculitis or other cerebrovascular diseases
- malign brain tumours of brain tumours treated with radiotherapy;Exclusion criteria for patients
- Allergic reaction to gadolinium
- Patients who are already treated with medication for cerebral vasculitis
when included
- Patients with impaired renal function (severe renal insufficiency, GFR
<30ml/min/1,73m2; or nephrogenic systemic fibrosis/ nephrogenic fibrosing
nephropathy (NSF/NFG))
- Impossibility to undergo MRI (claustrophobia, implants or metal objects in
or around the body)
- Pregnancy
-Malign brain tumour or brain tumours treated with radiotherapy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the sensitivities and specificities of the<br /><br>diagnosis based on the standard clinical work-up and the 7T MRI scans. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameter is the presence or absence of intracranial vessel<br /><br>wall abnormalities in the two studied groups</p><br>