Children*s Autoimmunity related to Neuropsychiatric symptoms, Chorea and Epilepsy

Recruiting

• Conditions: 'autoimmune encephalitis' and 'inflamed brain'; 10003816; 10007951; 10037173

• Registration Number: NL-OMON41693
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 600

Inclusion Criteria

- Age under 18 years
- Clinical profile fits one of the four groups: 1. limbic or cortical encephalitis, 2. new-onset seizures/status epilepticus without known cause, 3. acute encephalopathy with fever/inflammation-mediated status epilepticus or 4. acute-onset neuropsychiatric symptoms of basal ganglia dysfunction, like chorea .
- No known cause, like a bacteria, virus, haemorrhage, stroke, genetic cause.

Exclusion Criteria

- 18 years or over
- Patient and/ or legal representative is withholding informed consent
- Patient objects after initial informed consent (see paragraph 8.3).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. The characterization of new antibody-related clinical syndromes; 2. The<br /><br>frequency of the individual antibody-mediated syndromes in children; 3. The<br /><br>outcome of the individual antibody-mediated syndromes in children. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>