The Effect of Water Intake on Glucose Regulation: A Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Glucose Metabolism Disorders
- Sponsor
- Arizona State University
- Primary Endpoint
- metabolic clearance rate for insulin
- Status
- Withdrawn
- Last Updated
- 6 years ago
Overview
Brief Summary
There is a growing body of evidence suggesting low water intake and elevated levels of the hormone vasopressin exacerbate glucose regulation. This project will examine the physiological mechanism by which low water intake impairs glucose homeostasis.
In the current proposal we aim to: 1) quantify the degree of glucose impairment as a response to elevated vasopressin due to low water intake and 2) identify the physiological mechanism by which elevated vasopressin, as a response to low water intake, impairs glucose regulation
Investigators
Stavros Kavouras
Professor of Nutrition
Arizona State University
Eligibility Criteria
Inclusion Criteria
- •BMI 27.5-35
Exclusion Criteria
- •BMI \<27.5 or \>35
- •high physical activity
- •impaired liver or kidney function
- •cardiovascular disease
- •weight change of more than 3 kg in the past month
- •pregnancy
- •previous surgery on digestive tract (except appendectomy)
- •fluid balance will be exclusionary such as
- •serotonin re-uptake inhibitors.
Outcomes
Primary Outcomes
metabolic clearance rate for insulin
Time Frame: 220-240 min & 340-360 min of the protocol
metabolic clearance rate for insulin during the euglycemic \& Hyperglycemic clamp
amount of glucose metabolized M
Time Frame: 220-240 min & 340-360 min of the protocol
amount of glucose metabolized during the euglycemic \& Hyperglycemic clamp
quantity of glucose metabolized per unit plasma insulin concentration
Time Frame: 220-240 min & 340-360 min of the protocol
quantity of glucose metabolized per unit plasma insulin concentration during the euglycemic \& Hyperglycemic clamp
Rate of glucose appearance & disappearance
Time Frame: 220-240 min & 340-360 min of the protocol
Rate of glucose appearance \& disappearance during the euglycemic \& Hyperglycemic clamp
Secondary Outcomes
- glucagon(0 min, 240 min & 360 min of the protocol)
- Plasma copeptin(0 min, 240 min & 360 min of the protocol)
- Cortisol(0 min, 240 min & 360 min of the protocol)