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临床试验/NCT00143650
NCT00143650已完成1 期

Does House Dust From Water Damaged Buildings Cause Stronger Responses Among Occupants Than Dust From Buildings Without Water Damage? Can Occupants' Sensitivity be Predicted by Biomarkers?

University of Aarhus2 个研究点 分布在 1 个国家目标入组 27 人开始时间: 2001年1月最近更新:
适应症

试验速览

阶段
1 期
状态
已完成
入组人数
27
试验地点
2
主要终点
Acoustic rhinometry, general symptoms, inflammation

研究概览

简要总结

The study is focussed on two main questions:

  1. The importance of dampness of the building and home dust as a factor of the subjects= responses.
  2. Can measures used in KLINIR predict the subjects' responses to the dust?

This study therefore was arranged to test the following hypotheses:

  1. Does dust in general cause inflammatory/body perceptions through e.g. an irritation symptoms index.
  2. Does the dust include effective odorants which affects an IAQ index?
  3. Does dampness increase the content of organic or inorganic compounds e.g. of microbial origin that causes the dust to be more reactive? (Differences between the two types of dust)
  4. Is the sensitivity of the subjects explaining the responses to exposures in a, b, or c? (Subject group and sensitivity index)

As explorative investigations biomarkers for exposures and sensitivity for practical usage are tested.

详细描述

The study is focussed on two main questions:

c. The importance of dampness of the building and home dust as a factor of the subjects= responses.

d. Can measures used in KLINIR predict the subjects' responses to the dust?

As explorative investigations biomarkers for exposures and sensitivity are tested for practical use.

These investigations are made during experimental exposures of subjects to dust from dry and water damaged buildings. The responses of healthy KLINIR-sensitive subjects are predicted using personal sensitivity measures.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Crossover
主要目的
Prevention
盲法
Double

入排标准

年龄范围
18 Years 至 64 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • All in local area, nasal histamine responsive, grass allergic, from study KLINIR.

排除标准

  • Pregnancy, house dust allergy, hyper-responding air ways, disease, disabled

结局指标

主要结局

Acoustic rhinometry, general symptoms, inflammation

次要结局

未报告次要终点

研究者

申办方类型
Other

研究点 (2)

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