Alterations in Postprandial Glucose and Lipid Metabolism in Patients With Obstructive Sleep Apnea

Not Applicable

Completed

• Conditions: Obstructive Sleep Apnea
• Interventions: Device: CPAP treatment

• Registration Number: NCT00942110
• Lead Sponsor: Kyoto University, Graduate School of Medicine

Brief Summary

The purpose of this study is to examine postprandial glucose and lipid metabolism in patients with obstructive sleep apnea.

Detailed Description

Obstructive sleep apnea (OSA) is an increasingly prevalent condition that is characterized by repetitive upper airway obstructions. OSA has been independently associated with insulin resistance, suggesting that OSA may contribute to the development of type 2 diabetes and the metabolic syndrome. Recently, postprandial glucose and lipid have been reported as excellent predictors for mortality and cardiovascular risk. However, the association between postprandial glucose, lipid metabolism and OSA are not clear. In addition, humoral factors such as ghrelin and leptin are associated with obesity and OSA, but postprandial changes of which in patients with OSA are not well known. The aim of present study is to examine postprandial glucose and lipid metabolism, humoral factors in OSA before and after 3 months of continuous positive airway pressure (CPAP) treatment.

Study Timeline

• Study First Submitted: 2009-07-17
• Study First Submitted QC: 2009-07-17
• Study First Posted: 2009-07-20
• Study Start: 2009-09
• Primary Completion: 2011-12
• Status Verified: 2012-03
• Study Completion: 2012-03
• Last Update Submitted: 2012-03-05
• Last Update Posted: 2012-03-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• Subjects on admission for sleep study under the Respiratory Care and Sleep Control Medicine, Kyoto University Hospital.
• Subjects diagnosed with OSA (apnea hypopnea index >=5/hour) by overnight polysomnography.

Exclusion Criteria

• Subjects treating for acute infections or malignancy.
• Subjects with severe anemia, diabetes,and renal failure.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
CPAP	CPAP treatment	-

Primary Outcome Measures

Name	Time	Method
postprandial metabolic markers including glucose, cholesterol, triglyceride, ghrelin, leptin	baseline and 3 months after CPAP

Secondary Outcome Measures

Name	Time	Method
respiratory events (ie. apnea-hypopnea index)	baseline and 3 months after CPAP
inflammatory biomarkers (ie. IL-6, CRP)	baseline and 3 months after CPAP
quality of life	baseline and 3 months after CPAP
sleep quality	baseline and 3 months after CPAP
sympathetic activity in urine	baseline and 3 months after CPAP
appetite	baseline and 3 months after CPAP
endothelial function	baseline and 3months after CPAP

Trial Locations

Locations (1)

Kyoto University Graduate School of Medicine; 🇯🇵 Kyoto, Japan