SELECTIVE INTRACORONARY HYPOTHERMIA IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION TO REDUCE INFARCT SIZE
- Conditions
- heart attackmyocardial infarction10011082
- Registration Number
- NL-OMON48678
- Lead Sponsor
- Catharina-ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Patients will be eligible for this study if they are admitted for acute anterior wall ST-elevation myocardial infarction with a total ST-segment deviation of at least 5 mm and presenting within 6 hours after onset of complaints.
Patients should have a TIMI 0 or 1 flow in the infarction related artery.
Patients should be hemodynamically stable and in an acceptable clinical condition.
* Age <18 year or >80 year
* Cardiogenic shock or hemodynamically unstable patients
* Patients with previous myocardial infarction in the culprit artery of with previous bypass surgery
* Very tortuous or calcified coronary arteries
* Complex or long-lasting primary PCI expected
* Severe concomitant disease or conditions with a life expectancy of less than one year
* Inability to understand and give informed consent
* Known contra-indication for MRI
* Pregnancy
* Severe conduction disturbances necessitating implantation of temporary Pacemaker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>PRIMARY ENDPOINT<br /><br>Infarct size (as a percentage of total left ventricular mass) on MRI at 3<br /><br>months after the index event. </p><br>
- Secondary Outcome Measures
Name Time Method