Effects of a combined functional walking and strength trainig on the stability of walking and the rate of bone turnover in inactive, but healthy elderly

Recruiting

Conditions: veroudering
aging
senescent

Registration Number: NL-OMON35091

Lead Sponsor: Vrije Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- man/woman between the age of 65-75 years
- not meet the requirements of the Nederlandse Norm Gezond Bewegen (NNGB) --> less than 5 x 30 min. per week active
- no active participation in sports for the last year

Exclusion Criteria

- Chronic (progressive) disorder which affects the sensory or motor function (i.e. CVA, Parkinson, severe arthritis)
- cardiac problems (heart failure, aneurysm, heart rhythm complaints, claudicatio intermittens) over the past 10 years
- thrombosis or emboli over the past 10 years
- Instable metabolic disorder (i.e. diabetes)
- bone fracture over the past 2 years
- Vertebra collapse
- Walking with walking aid
- Cognitive limitations;The in- and exclusion criteria will be asked during a conversation on the phone. In addition, the Mini-Mental State Examination will be taken to get an impression about their cognitive abilities. People scoring *27 will be excluded from the study.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are:<br /><br>- to measure the stability of walking: the Lyapunov exponent<br /><br>- to measure the rate of bone turnover: CTx (C-terminal<br /><br>cross-linking-telopeptide of type 1 collagen) which is a biochemical marker of<br /><br>bone resorption and osteocalcin and P1NP (procollagen typ-1 N propeptide) as<br /><br>markers of bone formation will be measured.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are:<br /><br><br /><br>for gait measurements:<br /><br>- electromyography (EMG)<br /><br>- oxygen consumption<br /><br><br /><br>for muscle function:<br /><br>- cm (horizontal jump height)<br /><br>- force<br /><br>- EMG<br /><br>- serum concentration of the systemic growth factors IGF-1 and myostatin<br /><br><br /><br>for bone quality<br /><br>- in order to measure the quality of the heel bone broad band ultrasound<br /><br>attenuation (BUA) and speed of sound (SOS) will be measured, using quantitative<br /><br>ultrasound<br /><br><br /><br>for daily actitivies<br /><br>- LASA physical activity questionnaire (LAPAQ)</p><br>