MicroRNA expression profiles of blood in cardiovascular disease

Recruiting

• Conditions: coronary artery disease; coronary atherosclerosis; 10011082; 10003216

• Registration Number: NL-OMON35241
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Cases: men with coronair artery disease under the age of 51 years and a positive family history of premature CVD.
Controls: matched for sex, age and smoking habits

Exclusion Criteria

Cases: no cardiovascular event below 51 years
Controles: history or complaints of cardiovascular disease, positive family history of cardiovascular disease, use of medication. Additional exclusion criteria because of carbasaalcalcium and statin administration:
- Allergy for carbasalaatcalcium or simvastatin.
- Liver function disorders defined as the upper normal limit of ALAT and ASAT
- CPK above three time upper normal limit
- Renal impairement
Additional exclusion criteria for carbasalaatcalcium use:
- Gastric pain or complaints with former use
- Gastric bleeding or perforations
- Ulcers in stomach, esophagus or bowels
- Hypoprothrombinemia
Additional exclusion criteria for statin use:
- Consumption of excessive amount of alcohol defined as 21 units/week
- Hypothyoidism
- Familiar muscle disorders

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>MiRNA expression patterns of thrombocytes, monocytes, plasma and endothelial<br /><br>cells.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>