MicroRNA expression profiles of blood in cardiovascular disease - MiRNAs in CVD

Academisch Medisch Centrum0 个研究点目标入组 80 人开始时间: 待定最近更新: 2024年5月6日

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•Cases: men with coronair artery disease under the age of 51 years and a positive family history of premature CVD.
•Controls: matched for sex, age and smoking habits

•Cases: no cardiovascular event below 51 years
•Controles: history or complaints of cardiovascular disease, positive family history of cardiovascular disease, use of medication. Additional exclusion criteria because of carbasaalcalcium and statin administration:
•- Allergy for carbasalaatcalcium or simvastatin.
•- Liver function disorders defined as the upper normal limit of ALAT and ASAT
•- CPK above three time upper normal limit
•- Renal impairement
•Additional exclusion criteria for carbasalaatcalcium use:
•- Gastric pain or complaints with former use
•- Gastric bleeding or perforations
•- Ulcers in stomach, esophagus or bowels
•- Hypoprothrombinemia
•Additional exclusion criteria for statin use:
•- Consumption of excessive amount of alcohol defined as 21 units/week
•- Hypothyoidism
•- Familiar muscle disorders

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