Efficacy of quetiapine in methamphetamine dependency
Phase 3
- Conditions
- Methamphetamine dependence.Mental and behavioural disorders due to use of other stimulants, including caffeine
- Registration Number
- IRCT20171106037290N1
- Lead Sponsor
- Kashan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Aged 18–65 years
History of MA and opioid co-abuse in the past year
Currently undergoing methadone maintenance treatment
Seeking treatment for MA abuse
Evaluated by the drug abuse section of the Structured Clinical Interview for DSM-IV
Exclusion Criteria
Suicide attempts within the past 6 months or either suicidal ideations or psychotic symptoms in the past 6 months as determined by a study physician
Current alcohol or sedative physical dependence or cocaine dependence
Major cardiovascular disturbance
Metabolic diseases (e.g., neurological diseases and diabetes).
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method egative urine test for methamphetamine. Timepoint: Once every fifteen days. Method of measurement: methamphetamine urine test.;Depression. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Beck Depression Inventory (BDI).;Anxiety. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Beck Anxiety Inventory (BAI).;Sleep quality. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Pittsburgh Sleep Quality Index (PSQI).;Craving. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Desire for Drug Questionnaire (DDQ craving).;Withdrawal. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Amphetamine Withdrawal Questionnaire (AWQ).
- Secondary Outcome Measures
Name Time Method Risky Decision Making. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Iowa Gambling Task (IGT).;Memory. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Wechsler Logic Memory.;Verba Fluency. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: FAS task.;Speed Processing. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Digit Symbol and Trial Making Test (TMT).