Evaluation of short- und long-term morbidity of bowel mobilisation in patients with epithelial ovarian cancer after primary undergoing debulking surgery with special interest on Low anterior resection syndrome (LARS) - a retrospective analysis.

Recruiting

• Conditions: C56; K59; Malignant neoplasm of ovary; Other functional intestinal disorders

• Registration Number: DRKS00016155
• Lead Sponsor: Kliniken Essen-MitteAbteilung für Gynäkologie und Gyn. Onkologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 400

Inclusion Criteria

Ovarian cancer patients who underwent resection of sigma / rectosigmoid or deep anterior rectal resection during debulking surgery (period 2011-2018) will be recruited in this study. As a control cohort (this group will also be interviewed using the LARS questionnaire to record LARS score):
1) Patients who have also been treated for primary ovarian cancer but who did not receive bowel surgery as part of the debulking surgery; 2) breast cancer patients (matched-pair) who had neo / adjuvant chemotherapy based on breast cancer diagnosis, and no history of abdominal surgery .

Exclusion Criteria

All patients with diverting ostomy, postoperative anastomotic leak, history of abdominal radiotherapy.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The aim of the present study is to evaluate the prevalence of the low anterior resection syndrome (LARS) in patients with advanced epithelial ovarian cancer..

Secondary Outcome Measures

Name	Time	Method
• Comparison of the prevalence of LARS in patients with ovarian cancer with and without sigma / rectosigmoid or deep anterior rectal resection and breast cancer patients who had no abdominal / intestinal surgery.<br>• Prevalence of minor LARS and major LARS in patients with ovarian cancer after sigma / rectosigmoid or deep anterior rectal resection.<br>* Evaluation of risk factors for LARS