Vitreous concentration of moxfloxacin and bacterial isolation during vitreous surgery
- Conditions
- Vitreoretinal diseases
- Registration Number
- JPRN-UMIN000001942
- Lead Sponsor
- Osaka University Hospital, Department of Ophthalmology
- Brief Summary
Of the 81 eyes (40 eyes in the 25-gauge MIVS group; 41 eyes in the 20-gauge PPV group), the incidences of positive bacterial isolation at the 4 time points of sample collection were 77.5%, 62.3%, 22.5%, and 0% in the former group and 82.9%, 63.4%, 2.4%, and 0% in the latter group. Although the rate of bacterial contamination of the ocular surface significantly (P=0.001) decreased after preoperative moxifloxacin administration in both groups, transconjunctival 25-gauge MIVS had a significantly (P=0.007) higher incidence of vitreous contamination at the beginning of surgery compared with conventional 20-gauge PPV. The multivariate model showed that 25-gauge MIVS (odds ratio, 11.27; P=0.027; 95% confidence interval, 1.31-96.79) was the factor prognostic of vitreous contamination at the beginning of surgery. Propionibacterium acnes was identified most often in the vitreous samples (80% of cases), which was consistent with the commensal bacteria isolated from the ocular surface.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 80
Not provided
past history of vitreous surgery (vitrectomized eyes)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The rate of bacterial contamination in the vitreous samples obtained at the beginning and end of surgery
- Secondary Outcome Measures
Name Time Method Vitreous concentration of moxifloxacin and disinfection rate of conjunctival sac